What is CIN I-II-III ?

What is CIN?

CIN is an acronym for Cervical Intraepithelial Neoplasia. This term refers to a condition in the cervix where cells grow abnormally. Even though the term "neoplasia" means cancer in Latin, CIN does not necessarily mean cancer.

CIN is divided into three different degrees depending on the rate of cell growth and how far the growth has spread: CIN 1, CIN 2, and CIN 3.

  • CIN 1: Cell changes only affect a small portion of cells below the surface. This is generally a low-risk condition. When left to their natural processes without receiving additional treatment, 62.7% of patients diagnosed with CIN 1 return to normal cell structure through a natural recovery process. The risk of patients with CIN 1 becoming cancerous is at the 0.15% level.
  • CIN 2: Cell changes affect approximately half of the cells below the surface. This condition is higher risk and can turn into more serious cell abnormalities over time if untreated. 35.03% of patients diagnosed with CIN 2 regress to the CIN 1 (LSIL) level. It is difficult to know how many CIN 2 patients will progress to CIN 3. Since there may be overlooked CIN 3 lesions in some areas of the cervix while there are CIN 2 in others, CIN 2 patients are treated as if they were CIN 3.
  • CIN 3: Cell changes affect the entire layer of cells below the surface. This is the highest risk condition and there is a risk of turning into cervical cancer if untreated.

How is CIN diagnosed?

CIN (Cervical Intraepithelial Neoplasia) is usually diagnosed with colposcopy and biopsy. Colposcopy is the process of examining the cervix using a special microscope. After abnormal looking areas are identified, cell samples are taken from these areas. This process is called a biopsy. The samples taken are examined under a microscope in a laboratory environment and a pathology report is prepared.


What are LSIL and HSIL?

  • LSIL (Low-grade Squamous Intraepithelial Lesion): LSIL shows a slight level of abnormal change in cells. LSIL usually indicates the early stages of HPV (Human Papilloma Virus) infection and is mostly synonymous with CIN 1. These cell changes are usually temporary, and the body usually successfully fights the infection and the cells return to normal.
  • HSIL (High-grade Squamous Intraepithelial Lesion): HSIL shows more serious cell abnormalities and has a higher potential to turn into cervical cancer. HSIL is usually synonymous with CIN 2 and CIN 3 and may require faster and more aggressive treatment.

How is LSIL/HSIL diagnosed?

LSIL/HSIL is diagnosed by a smear test (Pap Smear). This is a screening test where cell samples are taken from the cervix. The smear test is used to detect abnormal cells and if any abnormalities are found in this test, a biopsy is recommended for a more detailed examination.


What is the difference between CIN1,2,3 and LSIL/HSIL classifications?

LSIL and HSIL are usually determined by a Pap smear (or Pap test). This test is done by examining cell samples taken from the cervix in a laboratory. The Pap smear test is used to detect abnormalities at the cellular level, and this helps prevent cervical cancer with early intervention and treatment.

CIN is usually determined by a biopsy. Biopsy is a more invasive test usually done during a colposcopy (an enlarged view of the cervix). During this procedure, the doctor takes a small tissue sample from the cervix. This tissue sample is then examined under a microscope in the lab. The degree of CIN (CIN 1, CIN 2, or CIN 3) depends on the severity and prevalence of cell abnormalities.

In conclusion, while Pap smear tests usually determine LSIL and HSIL, CIN is usually determined by a biopsy. Both tests are used to detect abnormalities in cervical cells, but they provide different levels of detail.


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  • What is CIN 1 CIN 2 and CIN 3?
  • Is CIN 2 and CIN 3 a cancer?
  • Is CIN Grade 3 cancer?
  • Is CIN 3 stage 0 cancer?
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  • What is a cervical intraepithelial neoplasia?
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